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The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retrospective analysis in patients affected by resected colorectal cancer treated with adjuvant FOLFOX regimen, Expert Opinion on Drug Safety, Informa Healthcare - 0 views

informahealthcare.com/...14740338.2011.562888

SAMe methylation cancer CBS cystathionine Beta-synthase glutathione GSH chemotherapy

shared by Nathan Goodyear on 27 Jun 12 - No Cached

Nathan Goodyear on 27 Jun 12

SAMe shown to lower liver toxicity in chemotherapy treatment. SAMe could be a powerful chemotherapeutic adjuvant. This makes since, because cancer is known to be a hypomethylated state. Low methyl donors will reduce CBS activity and thus lower glutathione. This will result in increased oxidative stress and inflammation in the liver. SAMe will open the CBS activity up and increase glutathione production.

<div class="cArrow"> </div><div class="cContentInner">SAMe shown to lower liver toxicity in chemotherapy treatment. SAMe could be a powerful chemotherapeutic adjuvant. This makes since, because cancer is known to be a hypomethylated state. Low methyl donors will reduce CBS activity and thus lower glutathione. This will result in increased oxidative stress and inflammation in the liver. SAMe will open the CBS activity up and increase glutathione production.</div>

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